The black circles reveal active web site Glu249 and the a few-residue loop (G-V227-G), which are in stick representation where oxygen and purple atoms are coloured purple and blue
Furthermore, residue His139, which is predicted to be doubly protonated, kinds a cost-dipole interaction across the interfINNO-206ace with the Cterminal of helix (a11). Stabilization of the interface is further improved…