However, deficiency of thorough concentration and kinetic information might make it hard to use some modeling approaches [sixty four]. Hence, nonparametric modeling supplies an substitute modeling method to examination hypothetical signaling networks
We simulated the activation state of CREB, ERK, HistH3, HSP27, p90, IkB, JNK, MEK, p38, and p70s6 proteins in human hepatocyte cells beneath activation of IL1b, TGFa, HER, INS, TNFa…