Name :
Recombinant Human Psoriasin/S100A7 Protein
Biological Activity :
Background :
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
NP_002954.2
NCBI Gene ID :
Synonyms :
Synonyms :
S100 calcium binding protein A7
Amino Acid Sequence :
Molecular Weight :
The recombinant human S100A7 consisting of 101 amino acids and migrates as an 11.6 kDa band in SDS-PAGE under reducing conditions as predicted.
Purity :
> 98 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the native human S100A7 (NP_002954.2) (Met 1-Gln 101) was expressed.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
PSOR1 Protein, Human; S100A7c Protein, Human Psoriasin/S100A7 背景信息 Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.
References & Citations :
Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23. Watson, PH. et al., 1998, Int J Biochem Cell Biol 30 (5):567-71. Emberley, ED. et al., 2004, Breast Cancer Res 6 (4): 153-9. Ohuchida, K. et al., 2006, Clin Cancer Res 12 (18):5417-22. Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38. León, R. et al., 2009, Biochemistry. 48 (44): 10591-600.
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