Name :
Recombinant Human LSAMP Protein (hFc Tag)
Biological Activity :
Background :
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning, and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there has been found that rats with an increased level of anxiety had 1.6-fold higher expression of the LsAMP gene in the periaqueductal gray compared to rats with a low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.
Biological Activity :
1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human OPCML-His (Cat:10328-H08H) at 10 μg/mL can bind recombinant human LSAMP-Fc with a linear range of 31.25-250 ng/ml.
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
Q13449
NCBI Gene ID :
Synonyms :
Synonyms :
limbic system-associated membrane protein
Amino Acid Sequence :
Molecular Weight :
The secreted recombinant human LSAMP/Fc is a disulfide-linked homodimer. Yhe reduced monomer consists of 528 amino acids and has a predicted molecular mass of 59 kDa. As a result of glycosylation, the apparent molecular mass of rhLSAMP/Fc monomer is approximately 80-85 kDa in SDS-PAGE under reducing conditions.
Purity :
> 97 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was was fused with the Fc region of human IgG1 at the C-terminus.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
FLJ34254 Protein, Human; FLJ35396 Protein, Human; FLJ37216 Protein, Human; FLJ54658 Protein, Human; IGLON3 Protein, Human; LAMP Protein, Human LSAMP 背景信息 The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning, and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there has been found that rats with an increased level of anxiety had 1.6-fold higher expression of the LsAMP gene in the periaqueductal gray compared to rats with a low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.
References & Citations :
Zacco A. et al., 1990, The Journal of Neuroscience. 10(1): 73-90. Pimenta AF. et al., 1996, Gene. 170(2) :189-95.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
NFE2L2 Proteinmanufacturer
OX40/TNFRSF4 ProteinFormulation
Popular categories:
Gastrin
CD4