Name :
Recombinant Human FHIT Protein (His Tag)
Biological Activity :
Background :
Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically – induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It also acts as a tumor suppressor of HER2/neu driven breast cancer.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
P49789
NCBI Gene ID :
Synonyms :
Synonyms :
fragile histidine triad
Amino Acid Sequence :
Molecular Weight :
The recombinant human FHIT consists of 153 amino acids and predicts a molecular mass of 17.7 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 85 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the human FHIT (P49789) (Met1-Gln147) was expressed with a polyhistidine tag at the C-terminus.
Buffer Solution :
Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
AP3Aase Protein, Human; FRA3B Protein, Human FHIT 背景信息 Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically – induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It also acts as a tumor suppressor of HER2/neu driven breast cancer.
References & Citations :
Lambert N, et al. (2006) An RNA gene expressed during cortical development evolved rapidly in humans. Nature. 443(7108):167-72. Pekarsky Y, et al. (1998) Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci. 95(15):8744-9. Ohta M, et al. (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell. 84(4): 587-97. (function(){if (!document.body) return;var js = “window[‘__CF$cv$params’]={r:’86b43c187fbb880c’,t:’MTcxMTU5MzQwOS40NzgwMDA=’};_cpo=document.createElement(‘script’);_cpo.nonce=”,_cpo.src=’/cdn-cgi/challenge-platform/scripts/jsd/main.js’,document.getElementsByTagName(‘head’)[0].appendChild(_cpo);”;var _0xh = document.createElement(‘iframe’);_0xh.height = 1;_0xh.width = 1;_0xh.style.position = ‘absolute’;_0xh.style.top = 0;_0xh.style.left = 0;_0xh.style.border = ‘none’;_0xh.style.visibility = ‘hidden’;document.body.appendChild(_0xh);function handler() {var _0xi = _0xh.contentDocument || _0xh.contentWindow.document;if (_0xi) {var _0xj = _0xi.createElement(‘script’);_0xj.innerHTML = js;_0xi.getElementsByTagName(‘head’)[0].appendChild(_0xj);}}if (document.readyState !== ‘loading’) {handler();} else if (window.addEventListener) {document.addEventListener(‘DOMContentLoaded’, handler);} else {var prev = document.onreadystatechange || function () {};document.onreadystatechange = function (e) {prev(e);if (document.readyState !== ‘loading’) {document.onreadystatechange = prev;handler();}};}})();
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