Product Name: Anti-CBX4 antibody produced in rabbit
Synonym: Anti-Chromobox homolog 4 (Pc class homolog, Drosophila)
Product Type: Chemical
CAS NO: 1187187-10-5Notch inhibitors
antibody Form: affinity isolated antibody
application(s)
immunohistochemistry: suitable
western blot: suitable
biological source
rabbit
clone
polyclonal
Concentration: 0.5 mg – 1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: mol wt 61 kDa
NCBI accession no.
NP_003646
Shipped in: wet ice
species reactivity
canine, bovine, guinea pig, mouse, human, zebrafish, rabbit, rat
Storage temp.: −20°C
Application: Anti-CBX4 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable.
Biochem/physiol Actions:
CBX4 belongs to the Polycomb group of proteins that are involved in determining stem cell pluripotency, identity and epigenetic gene silencing. CBX4 exhibits E3 sumo ligase activity that is directly involved in DNA damage response pathway. It interacts with p63 and regulates the transcription of genes that maintain the stemness of epithelial progenitors. CBX4 has a non-redundant role in T-cell proliferation and thymic organogenesis.
Immunogen:
The immunogen for anti-CBX4 antibody: synthetic peptide derected towards the N terminal of human CBX4
Physical Form: Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence:
Synthetic peptide located within the following region: LLIAFQNRERQEQLMGYRKRGPKPK
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/329/2/403.2