Product Name :
H2L 5765834
Description:
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.
CAS:
420841-84-5
Molecular Weight:
404.33
Formula:
C21H12N2O7
Chemical Name:
2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
Smiles :
OC(=O)C1=CC2=C(C=C1)C(=O)N(C1=CC(=CC=C1)OC1C=CC(=CC=1)N(=O)=O)C2=O
InChiKey:
HFYPTENHTPNXGP-UHFFFAOYSA-N
InChi :
InChI=1S/C21H12N2O7/c24-19-17-9-4-12(21(26)27)10-18(17)20(25)22(19)14-2-1-3-16(11-14)30-15-7-5-13(6-8-15)23(28)29/h1-11H,(H,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.4-Hydroxynonenal Aldehyde Dehydrogenase (ALDH)
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.|Product information|CAS Number: 420841-84-5|Molecular Weight: 404.33|Formula: C21H12N2O7|Chemical Name: 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid|Smiles: OC(=O)C1=CC2=C(C=C1)C(=O)N(C1=CC(=CC=C1)OC1C=CC(=CC=1)N(=O)=O)C2=O|InChiKey: HFYPTENHTPNXGP-UHFFFAOYSA-N|InChi: InChI=1S/C21H12N2O7/c24-19-17-9-4-12(21(26)27)10-18(17)20(25)22(19)14-2-1-3-16(11-14)30-15-7-5-13(6-8-15)23(28)29/h1-11H,(H,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Meropenem medchemexpress |Shelf Life: ≥12 months if stored properly.PMID:32757678 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|H2L 5765834 displays no effect on LPA2 or LPA4 receptors. H2L 5765834 inhibits LPA-induced platelet shape change with an IC50 of 13.73±2.52 μM.|In Vivo:|H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.|Products are for research use only. Not for human use.|