Product Name :
Liquiritin
Description:
Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.
CAS:
551-15-5
Molecular Weight:
418.39
Formula:
C21H22O9
Chemical Name:
7-hydroxy-2-(4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
Smiles :
OC1C=CC2=C(C=1)OC(CC2=O)C1C=CC(=CC=1)OC1OC(CO)C(O)C(O)C1O
InChiKey:
DEMKZLAVQYISIA-UHFFFAOYSA-N
InChi :
InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.Cetuximab In stock 62 μM, 0.Adavosertib Description 61 μM, and 3.PMID:33021409 72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.|Product information|CAS Number: 551-15-5|Molecular Weight: 418.39|Formula: C21H22O9|Chemical Name: 7-hydroxy-2-(4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one|Smiles: OC1C=CC2=C(C=1)OC(CC2=O)C1C=CC(=CC=1)OC1OC(CO)C(O)C(O)C1O|InChiKey: DEMKZLAVQYISIA-UHFFFAOYSA-N|InChi: InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 150 mg/mL (358.52 mM; Need ultrasonic). H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Liquiritin can target the residues Ala-27, Val-29, Ala-25, and Asn-56 of AKR1C1. Liquiritin (50 μM; 6 hours) results in 85.00% of reduction in progesterone metabolism, which is mediated by Aldo-keto reductase family 1 member C1 (AKR1C1) enzymatic activity in HEC-1-B cells. Liquiritin (100 µM) increases glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells.|Products are for research use only. Not for human use.|