Product Name :
TCO-PEG6-acid
Description:
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
CAS:
2353409-97-7
Molecular Weight:
505.60
Formula:
C24H43NO10
Chemical Name:
1-([(4Z)-cyclooct-4-en-1-yloxy]carbonylamino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
Smiles :
OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:31|
InChiKey:
ACASMHHVQBAVOG-UPHRSURJSA-N
InChi :
InChI=1S/C24H43NO10/c26-23(27)8-10-29-12-14-31-16-18-33-20-21-34-19-17-32-15-13-30-11-9-25-24(28)35-22-6-4-2-1-3-5-7-22/h1-2,22H,3-21H2,(H,25,28)(H,26,27)/b2-1-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 2353409-97-7|Molecular Weight: 505.Rifaximin Epigenetic Reader Domain 60|Formula: C24H43NO10|Chemical Name: 1-([(4Z)-cyclooct-4-en-1-yloxy]carbonylamino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid|Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:31||InChiKey: ACASMHHVQBAVOG-UPHRSURJSA-N|InChi: InChI=1S/C24H43NO10/c26-23(27)8-10-29-12-14-31-16-18-33-20-21-34-19-17-32-15-13-30-11-9-25-24(28)35-22-6-4-2-1-3-5-7-22/h1-2,22H,3-21H2,(H,25,28)(H,26,27)/b2-1-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.NPPB Biological Activity |Shelf Life: ≥12 months if stored properly.PMID:33084462 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.Products are for research use only. Not for human use.|