Name :
Recombinant Human KLHL2 Protein (GST Tag)
Biological Activity :
Background :
KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagus, and other tissues. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin-binding, and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane, and nucleus. It may also play a role in organizing the actin cytoskeleton of the brain cells. Diseases associated with KLHL2 include Mixed Malaria and Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
AAH36468.1
NCBI Gene ID :
Synonyms :
Synonyms :
kelch like family member 2
Amino Acid Sequence :
Molecular Weight :
The recombinant human KLHL2 /GST chimera consists of 540 amino acids and has a predicted molecular mass of 62.2 kDa. It migrates as an approximately 63 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 85 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the mature form of human KLHL2 (AAH36468.1) (Met1-Pro306) was fused with the GST tag at the N-terminus.
Buffer Solution :
Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
ABP-KELCH Protein, Human; KLHL2 Protein, Human; MAV Protein, Human; MAYVEN Protein, Human KLHL2 背景信息 KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagus, and other tissues. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin-binding, and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane, and nucleus. It may also play a role in organizing the actin cytoskeleton of the brain cells. Diseases associated with KLHL2 include Mixed Malaria and Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2.
References & Citations :
Minx P, et al. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 434:724-31. Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36:40-5. Jiang S, et al. (1999) Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 10:2361-75. (function(){if (!document.body) return;var js = “window[‘__CF$cv$params’]={r:’86b43698cd24512c’,t:’MTcxMTU5MzE4NC4yMTcwMDA=’};_cpo=document.createElement(‘script’);_cpo.nonce=”,_cpo.src=’/cdn-cgi/challenge-platform/scripts/jsd/main.js’,document.getElementsByTagName(‘head’)[0].appendChild(_cpo);”;var _0xh = document.createElement(‘iframe’);_0xh.height = 1;_0xh.width = 1;_0xh.style.position = ‘absolute’;_0xh.style.top = 0;_0xh.style.left = 0;_0xh.style.border = ‘none’;_0xh.style.visibility = ‘hidden’;document.body.appendChild(_0xh);function handler() {var _0xi = _0xh.contentDocument || _0xh.contentWindow.document;if (_0xi) {var _0xj = _0xi.createElement(‘script’);_0xj.innerHTML = js;_0xi.getElementsByTagName(‘head’)[0].appendChild(_0xj);}}if (document.readyState !== ‘loading’) {handler();} else if (window.addEventListener) {document.addEventListener(‘DOMContentLoaded’, handler);} else {var prev = document.onreadystatechange || function () {};document.onreadystatechange = function (e) {prev(e);if (document.readyState !== ‘loading’) {document.onreadystatechange = prev;handler();}};}})();
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