Name :
Recombinant Human IGSF11 Protein (His Tag), HPLC-verified
Biological Activity :
Background :
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
AAH34411.1
NCBI Gene ID :
Synonyms :
Synonyms :
immunoglobulin superfamily, member 11
Amino Acid Sequence :
Molecular Weight :
The secreted recombinant human IGSF11 consists of 229 amino acids and has a predicted molecular mass of 24.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 36 kDa due to glycosylation
Purity :
≥ 85 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the extracellular domain of human IGSF11 (AAH34411.1) (Met 1-Gly 240) was fused with a polyhistidine tag at the C-terminus
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
BT-IgSF Protein, Human; CT119 Protein, Human; CXADRL1 Protein, Human; Igsf13 Protein, Human; VSIG3 Protein, Human IGSF11 背景信息 Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.
References & Citations :
Toshimori K, et al. (2006) The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction. Reproductive Medicine and Biology. 5(2): 87-93.Coyne CB, et al. (2005) CAR: A virus receptor within the tight junction. Advanced Drug Delivery Reviews. 57(6) : 869-82.Watanabe T, et al. (2005) Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Cancer Science. 96(8) :498-506.
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