Name :
Recombinant Human GALNT2 Protein (His Tag)
Biological Activity :
Background :
GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. GALNT2 may play a role in lipid metabolism. It catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT2 has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
NP_004472.1
NCBI Gene ID :
Synonyms :
Synonyms :
polypeptide N-acetylgalactosaminyltransferase 2
Amino Acid Sequence :
Molecular Weight :
The recombinant human GALNT2 comprises 540 amino acids and has a predicted molecular mass of 61.6 kDa. The apparent molecular mass of the protein is approximately 57-65 and 46 kDa in SDS-PAGE under reducing conditions.
Purity :
> 95 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the human GALNT2 (NP_004472.1) (Lys52-Gln571) was expressed with an N-terminal polyhistidine tag.
Buffer Solution :
Lyophilized from sterile 25 mM Tris, 150 mM NaCl, 0.05% Brij-35, pH 7.5.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
GalNAc-T2 Protein, Human GALNT2 背景信息 GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. GALNT2 may play a role in lipid metabolism. It catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT2 has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b.
References & Citations :
Bennett EP. et al., 1998, Glycobiology. 8 (6): 547-55. White T. et al., 1995, J Biol Chem. 270 (41): 24156-65. Bennett EP. et al., 1996, J Biol Chem. 271 (29): 17006-12. Holleboom AG. et al., 2011, Cell Metab. 14 (6): 811-8.
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