Name :
Recombinant Human FRZB Protein (His Tag)
Biological Activity :
Background :
FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the Frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
NP_001454.2
NCBI Gene ID :
Synonyms :
Synonyms :
Frizzled-related protein
Amino Acid Sequence :
Molecular Weight :
The recombinant human FRZB comprises 304 amino acids and has a predicted molecular mass of 34.5 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions.
Purity :
> 85 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
FRE Protein, Human; FRITZ Protein, Human; FRP-3 Protein, Human; FRZB-1 Protein, Human; FRZB-PEN Protein, Human; FRZB1 Protein, Human; FZRB Protein, Human; hFIZ Protein, Human; OS1 Protein, Human; SFRP3 Protein, Human; SRFP3 Protein, Human FRZB 背景信息 FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the Frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
References & Citations :
Hoang B., et al.,(1996), Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila Frizzled, suggest a role in skeletal morphogenesis. J. Biol. Chem. 271:26131-26137.Mayr T., et al., (1997), Fritz: a secreted Frizzled-related protein that inhibits Wnt activity.Mech. Dev. 63:109-125.Leyns L., et al.,(1997), Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.Cell 88:747-756.
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