Name :
Recombinant Human FKBP25/FKBP3 Protein (GST Tag)
Biological Activity :
Background :
FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
Q00688
NCBI Gene ID :
Synonyms :
Synonyms :
FK506 binding protein 3
Amino Acid Sequence :
Molecular Weight :
The recombinant human FKBP3/GST chimera consists of 455 amino acids and has a predicted molecular mass of 52 kDa. It migrates as an approxiamtely 48 kDa band in SDS-PAGE under reducing conditions.
Purity :
> 90 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the human FKBP3 (Q00688) (Ala 2-Asp 224) was fused with the GST tag at the N-terminus.
Buffer Solution :
Lyophilized from sterile 50mM tris, 0.15M NaCl, 0.5mM GSH, pH 8.0Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
FKBP-25 Protein, Human; FKBP-3 Protein, Human; FKBP25 Protein, Human; PPIase Protein, Human FKBP25/FKBP3 背景信息 FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
References & Citations :
Wiederrecht G., et al., 1992, Biochem. Biophys. Res. Commun. 185: 298 – 303. Dephoure N., et al.,2008, Proc. Natl. Acad. Sci. USA.105:10762-7. Gauci S., et al., 2009, Anal. Chem. 81:4493-4501. Choudhary C., et al., 2009, Science. 325:834-840.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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