Name :
Recombinant Human Factor H-related 2/CFHR2 Protein (His Tag)
Biological Activity :
Background :
CFHR2 belongs to the complement Factor H protein family. The human complement Factor H protein family consists of the complement and immune regulators Factor H, the Factor H-like protein 1(FHL-1) and five Factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR2 contains 4 Sushi (CCP/SCR) domains and is expressed by the liver and secreted in plasma. CFHR2 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
P36980-1
NCBI Gene ID :
Synonyms :
Synonyms :
complement Factor H-related 2
Amino Acid Sequence :
Molecular Weight :
The recombinant human CFHR2 consists of 263 amino acids and predicts a molecular mass of 30.2 KDa. It migrates as an approximately 31 and 35 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 90 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the human CFHR2 (P36980-1) (Met1-Lys270) was expressed with a polyhistidine tag at the C-terminus.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
CFHL2 Protein, Human; FHR2 Protein, Human; HFL3 Protein, Human Factor H-related 2/CFHR2 背景信息 CFHR2 belongs to the complement Factor H protein family. The human complement Factor H protein family consists of the complement and immune regulators Factor H, the Factor H-like protein 1(FHL-1) and five Factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR2 contains 4 Sushi (CCP/SCR) domains and is expressed by the liver and secreted in plasma. CFHR2 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
References & Citations :
Skerka C, et al. (1991) Molecular cloning of a human serum protein structurally related to complement Factor H. J Biol Chem. 266(18):12015-20.Daz-Guilln MA, et al. (1999) A radiation hybrid map of complement Factor H and Factor H-related genes. Immunogenetics. 49(6):549-52.Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
CFHR4 Protein
Adiponectin/Acrp30 Protein
Popular categories:
UCH-L1
Siglec-10