Name :
Recombinant Human Factor H-related 1/CFHR1 Protein (His Tag)
Biological Activity :
Background :
CFHR1 is a secreted protein belonging to the complement Factor H protein family.The human complement Factor H protein family consists of the complement and immune regulators Factor H, the Factor H-like protein 1(FHL-1) and five Factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. CFHR1 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
Q03591
NCBI Gene ID :
Synonyms :
Synonyms :
complement Factor H related 1
Amino Acid Sequence :
Molecular Weight :
The recombinant human CFHR1 consists of 323 amino acids and predicts a molecular mass of 37.2 KDa. It migrates as an approximately 45 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 95 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the human CFHR1 (Q03591) (Met1-Arg330) was expressed with a polyhistidine tag at the C-terminus.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
CFHL Protein, Human; CFHL1 Protein, Human; CFHL1P Protein, Human; CFHR1 Protein, Human; CFHR1P Protein, Human; FHR1 Protein, Human; H36-1 Protein, Human; H36-2 Protein, Human; HFL1 Protein, Human; HFL2 Protein, Human Factor H-related 1/CFHR1 背景信息 CFHR1 is a secreted protein belonging to the complement Factor H protein family.The human complement Factor H protein family consists of the complement and immune regulators Factor H, the Factor H-like protein 1(FHL-1) and five Factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. CFHR1 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
References & Citations :
Martnez-Barrica, et al. (2012) Relevance of complement Factor H-related 1 (CFHR1) genotypes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 53(3):1087-94.Leban N, et al. (2012) Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations. Int J Immunogenet. 39(2):110-3.Kubista KE, et al. (2011) Copy number variation in the complement Factor H-related genes and age-related macular degeneration. Int J Immunogenet. Mol Vis. 17:2080-92.
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