Name :
Recombinant Human CCL27 Protein (His Tag)
Biological Activity :
Background :
CCL27, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27 is chemotactic for skin-associated memory T lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Through binding to the chemokine receptor 1 (CCR1), CCL27 mediates inflammation by promoting lymphocyte migration into the skin.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
Q9Y4X3
NCBI Gene ID :
Synonyms :
Synonyms :
chemokine (C-C motif) ligand 27
Amino Acid Sequence :
Molecular Weight :
The recombinant human CCL27 consists of 104 amino acids and predicts a molecular mass of 12.2 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 95 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the human CCL27 (Q9Y4X3) (Phe25-Gly112) was expressed with a polyhistidine tag at the N-terminus.
Buffer Solution :
Lyophilized from sterile 30% acetonitrile, 0.1% TFA.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
ALP Protein, Human; CCL27 Protein, Human; CTACK Protein, Human; CTAK Protein, Human; ESKINE Protein, Human; ILC Protein, Human; PESKY Protein, Human; SCYA27 Protein, Human CCL27 背景信息 CCL27, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27 is chemotactic for skin-associated memory T lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Through binding to the chemokine receptor 1 (CCR1), CCL27 mediates inflammation by promoting lymphocyte migration into the skin.
References & Citations :
Morales. et al., 1999, Proc Natl Acad Sci. 96: 14470-5. Homey. et al., 2002, J Immunol. 164: 3465-70. Ishikawa-Mochizuki. et al., 1999, FEBS Lett. 460: 544-8.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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