Name :
Recombinant Human Carbonic Anhydrase VII Protein (His Tag)
Biological Activity :
Background :
Carbonic Anhydrase 7, also known as carbonate dehydratase VII, Carbonic Anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-Carbonic Anhydrase family. Carbonic Anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic Anhydrases show extensive diversity in tissue distribution and in their subcellular localization. CA7 / CA-VII is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.
Biological Activity :
Measured by its esterase activity. The activity is >20 pmoles/min/μg.
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
P43166
NCBI Gene ID :
Synonyms :
Synonyms :
Carbonic Anhydrase VII
Amino Acid Sequence :
Molecular Weight :
The recombinant human CA7 consisting of 274 amino acids and has a calculated molecular mass of 31 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
Purity :
> 90 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the human CA7 (P43166) (Met 1-Ala 264) was fused with a polyhistide tag at the C-terminus.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
CAVII Protein, Human Carbonic Anhydrase VII 背景信息 Carbonic Anhydrase 7, also known as carbonate dehydratase VII, Carbonic Anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-Carbonic Anhydrase family. Carbonic Anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic Anhydrases show extensive diversity in tissue distribution and in their subcellular localization. CA7 / CA-VII is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.
References & Citations :
Montgomery J.C., et al., 1991, Genomics 11:835-848. Temperini C., et al., 2006, Chemistry 12:7057-7066. Temperini C., et al., 2007, Bioorg. Med. Chem. Lett. 17:628-635. Maresca A., et al., 2009, J. Am. Chem. Soc. 131:3057-3062.
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