Name :
Recombinant Human ADAM8/CD156a Protein (ECD, His Tag)
Biological Activity :
Background :
ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
HEK293 Cells
Tag :
Protein Accession No. :
AAI15405.1
NCBI Gene ID :
Synonyms :
Synonyms :
ADAM metallopeptidase domain 8
Amino Acid Sequence :
Molecular Weight :
The recombinant human ADAM8 consists of 648 amino acids and predicts a molecular mass of 71 kDa.
Purity :
> 95 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg protein as determined by the LAL method.
Protein Construction :
A DNA sequence encoding the human ADAM8 (AAI15405.1) (Met1-Ser653) was expressed with a polyhistidine tag at the C-terminus.
Buffer Solution :
Supplied as sterile 12.5 mM Tris, 5 mM CaCl2, 75 mM NaCl, 50% glycerol, pH 7.5.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
Liquid. It is shipped out with blue ice.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
CD156 Protein, Human; CD156a Protein, Human; MS2 Protein, Human ADAM8/CD156a 背景信息 ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
References & Citations :
Yoshiyama K., et al.,(1997), CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. Genomics 41:56-62.Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.Deloukas P., et al.,(2004), The DNA sequence and comparative analysis of human chromosome 10.Nature 429:375-381.
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