(Table 4). Several studies have shown that the exposure of cells to an inflammatory stimulus (IL-1 or TNF-) strongly down-regulated proteoglycan levels [27,48,52,53]. This reduction might occur via an inhibition of aggrecan mRNA [29] or an IL-1 and TNF–induced activation of proteases like ADAMTSs or MMPs, which in turn cleave proteoglycans [54]. It is noticeable …
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