Product Name: Anti-CTNNB1 (AB1) antibody produced in rabbit
Synonym: Anti-Catenin (cadherin-associated protein), β 1, 88 kDa
Product Type: Chemical
CAS NO: 1311982-88-3TAM Receptor inhibitors
antibody Form: IgG fraction of antiserum
application(s)
immunohistochemistry: suitable
western blot: suitable
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: lyophilized powder
Immunogen sequence: DPMMEHEMGGHHPGADYPVDGLPDL
Mol wt: mol wt 76 kDa
NCBI accession no.
NP_001091680
species reactivity
canine, pig, bovine, zebrafish, chicken, mouse, rat, human
Storage temp.: −20°C
Application: Anti-CTNNB1 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1.25 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable.
Biochem/physiol Actions:
β-catenin (CTNNB1) is a multifunctional protein that regulates development processes and cell adhesion. CTNNB1 interacts with Wnt signaling pathway and FoxM1 to regulate genes crucial for cell survival, angiogenesis, invasion and self-renewal. The cross talk of Wnt and CTNNB1 is important for signaling pathways in T cell maturation and neurodegenerative disorders such as Alzheimer′s disease and schizophrenia. The FoxM1-β-catenin pathway regulates tumorigenicity of glioma stem cells.
Immunogen:
synthetic peptide corresponding to a region of human CTNNB1 with an internal ID of S00103
Physical Form: Lyophilized from PBS buffer with 2% sucrose
RIDADR: NONH for all modes of transport
WGK Germany: 2
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/329/1/76